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Too much or too little myokine production can be problematic. Higher but still healthy production occurs during lower-intensity training. However, hard training and competition can raise the levels of myokines to dangerously high levels, which can promote inflammation, disturb the insulin mechanism, reduce muscle mass, and reduce the muscles’ ability to properly utilize glucose.
Other chemicals called oxygen free radicals are also released during training and competition. While these have great benefits in smaller amounts, anaerobic training and competition can produce much higher amounts contributing to muscle damage and other problems, especially when myokine levels are too low, or too high.
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